IgE‐associated food allergy alters the presentation of paediatric eosinophilic esophagitis

Summary Background Links between food allergens and eosinophilic esophagitis (EoE) have been established, but the interplay between EoE‐ and IgE‐associated immediate hypersensitivity to foods remains unclear. Objective We sought to determine the prevalence of IgE‐associated food allergy at the time of diagnosis of EoE in children and to determine whether differences existed in presentation and disease compared to subjects with EoE alone. Methods Eosinophilic esophagitis patients were stratified based on the diagnosis of IgE‐associated immediate hypersensitivity (EoE + IH vs. EoE− IH ). Clinical, histologic, pathologic, and endoscopic differences were investigated using a retrospective database. Results We found that 29% of the 198 EoE patients in our cohort had EoE + IH . These subjects presented at a younger age than those without IH (6.05 vs. 8.09 years, P = 0.013) and were more likely to have comorbid allergic disease. Surprisingly, the EoE + IH group presented with significantly different clinical symptoms, with increased dysphagia, gagging, cough, and poor appetite compared to their counterparts in the EoE− IH group. Male gender, allergic rhinitis, the presence of dysphagia, and younger age were independently associated with having EoE + IH . Specific IgE levels to common EoE‐associated foods were higher in EoE + IH , regardless of eliciting immediate hypersensitivity symptoms. In contrast, IgE levels for specific foods triggering EoE were relatively lower in both the groups than IgE levels for immediate reactions. Conclusions and Clinical Relevance Immediate hypersensitivity is common in children with EoE and identifies a population of EoE patients with distinct clinical characteristics. Our study describes a subtype of EoE in which IgE‐mediated food allergy may impact the presentation of paediatric EoE.