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Effect of the novel histamine H 4 receptor antagonist SENS‐111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss
Author(s) -
Petremann Mathieu,
Gueguen Cindy,
Delgado Betancourt Viviana,
Wersinger Eric,
DyhrfjeldJohnsen Jonas
Publication year - 2020
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/bph.14803
Subject(s) - nystagmus , vestibular system , antagonist , histamine , medicine , vestibulo–ocular reflex , chemistry , receptor , neuroscience , anesthesia , audiology , biology
Histamine H 4 receptors are expressed in the peripheral vestibular system, and their selective inhibition improves vertigo symptoms in rats with unilateral vestibular lesions. The effects of SENS-111, a selective oral H 4 receptor antagonist with high affinity to both animal and human receptors, on vertigo symptoms was evaluated in a translational in vivo model of unilateral vestibular loss.
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