Premium
Assessment of post‐partum haemorrhage risk among women with moderate thrombocytopenia
Author(s) -
Arcudi Sara,
Ronchi Alice,
Capecchi Marco,
Iurlaro Enrico,
Ossola Manuela W.,
Mancini Ilaria,
Schivardi Gabriella,
Marconi Anna Maria,
Podda Gian Marco,
Artoni Andrea
Publication year - 2022
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/bjh.18098
Subject(s) - medicine , odds ratio , confidence interval , risk factor , caesarean section , gynecology , platelet , post partum , vaginal delivery , obstetrics , caesarean delivery , pregnancy , genetics , biology
Summary It is unknown whether moderate thrombocytopenia represents a risk factor for post‐partum haemorrhage (PPH). We assessed PPH risk among women with a platelet count of between 100 and 50 × 10 9 /l and stratified the risk for O/non‐O blood group. We included consecutive women undergoing vaginal delivery or caesarean section with moderate thrombocytopenia. Women with >150 × 10 9 /l platelets at delivery were selected as controls and matched for age, type of birth and ethnicity. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were calculated as risk estimates. A total of 94 thrombocytopenic women and 94 controls were included in the study. The rate of PPH was significantly higher in thrombocytopenic women than in controls (37% vs. 10%, p < 0.001); there was a higher risk of PPH in the thrombocytopenic group when compared to the control group (adjusted OR 4.7, 95% CI 2.1–10.8, p < 0.01) and this association was stronger in blood group O carriers (adjusted OR 11.0, 95% CI 2.4–49.6, p < 0.01). In conclusion, our study shows that a moderate thrombocytopenia is a risk factor for PPH, especially in blood group O carriers.