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Donor sclera versus bovine pericardium as patch graft material in glaucoma implant surgery and the impact of a drainage suture
Author(s) -
Hoefen Wijsard Milo,
Haan Michiel,
Rietveld Eelco,
Rijn Laurentius J.
Publication year - 2018
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/aos.13721
Subject(s) - sclera , medicine , surgery , pericardium , cohort , glaucoma , intraocular pressure , fibrous joint , retrospective cohort study , ophthalmology
Abstract Purpose To compare the use of human donor sclera with bovine pericardium as patch graft material for a glaucoma drainage device ( GDD ), with respect to the incidence of tube exposure, and to study the role of a drainage suture. Methods All GDD surgeries between 2010 and 2014 performed at the VU Medical Center were examined in this comparative, retrospective cohort study. A total of 244 cases were included; 163 in the human donor sclera cohort and 81 in the bovine pericardium cohort with a median follow‐up of 31 and 36 months, respectively. The primary outcome measure was occurrence of tube exposure. Survival analysis for tube exposure was carried out and Kaplan–Meier curves compared. Secondary outcomes were postoperative intraocular pressure ( IOP ), number of glaucoma medications and the effect of a drainage suture. Results In the bovine pericardium cohort, eleven (13.6%) eyes developed tube exposure compared to none in the human donor sclera cohort. Their Kaplan–Meier survival curves differed significantly from each other ( χ ² = 21.1, p < 0.001, log‐rank test). Mean IOP and number of glaucoma medications did not differ significantly between patch graft materials at three months of follow‐up. The use of a drainage suture directly lowered IOP after surgery in both cohorts. Within the bovine pericardium cohort, eyes with a drainage suture experienced more tube exposure, although this difference was not statistically significant (p = 0.09). Conclusion Human donor sclera leads to less tube exposure than bovine pericardium. A drainage suture directly lowers IOP after surgery. With bovine pericardium, but not with donor sclera, exposure tends to be enhanced by a drainage suture.