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The change in Thiol–Disulphide Homeostasis levels as an oxidative stress marker after varicocelectomy: Is there a relationship with sperm parameters?
Author(s) -
Gok Bahri,
Gok Gamze,
Koc Erdem,
Hamidi Nurullah,
Alijla Amjad,
Asil Erem,
Gok Alper,
Kamaci Davut,
Neselioglu Salim,
Ener Kemal
Publication year - 2020
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/and.13515
Subject(s) - varicocele , oxidative stress , andrology , sperm , thiol , semen , infertility , motility , male infertility , chemistry , sperm motility , medicine , endocrinology , biology , biochemistry , microbiology and biotechnology , pregnancy , genetics
Abstract One of the most important causes of varicocele‐related infertility is oxidative stress (OS). One of the markers considered as an indicator of OS is thiol–disulphide homeostasis (TDH). Based on the hypothesis that OS should decrease after varicocelectomy in the light of this information, in our current study, we investigated the relationship between TDH levels and sperm parameters. The data of 56 infertile varicocele men were prospectively analysed. The post‐operative total and native thiol levels were significantly higher than those pre‐operative total and native thiol levels (477.7 & 436.7 nmol/L, 417.6 & 372.1 nmol/L). Positive correlation was found between total thiol change and change in semen volume ( ρ : .277, p : .039), ratio of spermatozoa with normal morphology ( ρ : .342, p : .01), progressive ( ρ : .334, p : .012) and nonprogressive motility ( ρ : .385, p : .003). Positive correlation was also found between native thiol change and semen volume ( ρ : .349, p : .008), ratio of spermatozoa with normal morphology ( ρ : .362, p : .006), progressive ( ρ : .297, p : .026) and nonprogressive motility ( ρ : .368, p : .005). Change in the level of TDH was found as positively correlated with progressive and nonprogressive motility change. According to these results, OS decreases with varicocelectomy in infertile patients and TDH can be used as a useful method for measuring OS.