Open AccessAbscopal effect induced by modulated radiation therapy and pembrolizumab in a patient with pancreatic metastatic lung squamous cell carcinoma
Author(s) -
Wang Weiwei,
Huang Cheng,
Wu Shafei,
Liu Zhikai,
Liu Lei,
Li Li,
Li Shanqing
Publication year - 2020
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.13427
Subject(s) - medicine , abscopal effect , radiation therapy , pembrolizumab , chemotherapy , oncology , metastasis , immunotherapy , squamous cell carcinoma of the lung , lung cancer , lung , carcinoma , radiology , cancer
The main recurrence pattern for lung cancer patients after radical surgery is distant metastasis. The probability of pancreatic metastasis in patients diagnosed with lung squamous cell carcinoma is 0.02%, with a poor prognosis. Chemotherapy is the preferred treatment for recurrence. Single lesions or oligometastasis can be surgically resected, and local lesions with compression symptoms can be treated with radiotherapy. The FDA and NMPA have approved first‐line indications for immunotherapy for lung squamous cell carcinoma. Here, we report the case of a 57‐year‐old male patient with lung squamous cell carcinoma who developed pancreatic metastasis after radical resection. The disease progressed after first‐line chemotherapy, and the patient was treated with immunotherapy combined with radiotherapy. We subsequently observed the abscopal effect of intensity modulated radiation therapy (IMRT) and pembrolizumab with disappearance of lung metastasis after radiotherapy for pancreatic metastasis. The patient’s tumor symptoms were relieved with prolonged survival.