A Partial Likelihood Estimator of Vaccine Efficacy | Zendy

Yip Paul S.F. | Zendy; Chen Qizhi | Zendy

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A Partial Likelihood Estimator of Vaccine Efficacy

Author(s) -

Yip Paul S.F.,

Chen Qizhi

Publication year - 2000

Publication title -

australian and new zealand journal of statistics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.434

H-Index - 41

eISSN - 1467-842X

pISSN - 1369-1473

DOI - 10.1111/1467-842x.00133

Subject(s) - mathematics , estimator , vaccine efficacy , maximum likelihood , statistics , generalized estimating equation , maximum likelihood sequence estimation , vaccination , medicine , virology

A partial likelihood method is proposed for estimating vaccine efficacy for a general epidemic model. In contrast to the maximum likelihood estimator (MLE) which requires complete observation of the epidemic, the suggested method only requires information on the sequence in which individuals are infected and not the exact infection times. A simulation study shows that the method performs almost as well as the MLE. The method is applied to data on the infectious disease mumps.

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