Nuclear Speckles | Zendy

David L. Spector | Zendy; Angus I. Lamond | Zendy

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Nuclear Speckles

Author(s) -

David L. Spector,

Angus I. Lamond

Publication year - 2010

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a000646

Subject(s) - nucleoplasm , biology , rna splicing , cell nucleus , microbiology and biotechnology , nucleus , speckle pattern , gene , rna , genetics , nucleolus , physics , optics

Nuclear speckles, also known as interchromatin granule clusters, are nuclear domains enriched in pre-mRNA splicing factors, located in the interchromatin regions of the nucleoplasm of mammalian cells. When observed by immunofluorescence microscopy, they usually appear as 20-50 irregularly shaped structures that vary in size. Speckles are dynamic structures, and their constituents can exchange continuously with the nucleoplasm and other nuclear locations, including active transcription sites. Studies on the composition, structure, and dynamics of speckles have provided an important paradigm for understanding the functional organization of the nucleus and the dynamics of the gene expression machinery.

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