An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels | Zendy

Edson Delatorre | Zendy; Milene Dias Miranda | Zendy; Diogo A. Tschoeke | Zendy; Patrícia Carvalho de Sequeira | Zendy; Simone Alves Sampaio | Zendy; Giselle Barbosa-Lima | Zendy; Yasmine Rangel Vieira | Zendy; Luciana Leomil | Zendy; Fernando A. Bozza | Zendy; José Cerbino-Neto | Zendy; Patrı́cia T. Bozza | Zendy; Rita Maria Ribeiro Nogueira | Zendy; Patrícia Brasil | Zendy; Fabiano L. Thompson | Zendy; Ana María Bispo de Filippis | Zendy; Thiago Moreno L. Souza | Zendy

Open Access

An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels

Author(s) -

Edson Delatorre,

Milene Dias Miranda,

Diogo A. Tschoeke,

Patrícia Carvalho de Sequeira,

Simone Alves Sampaio,

Giselle Barbosa-Lima,

Yasmine Rangel Vieira,

Luciana Leomil,

Fernando A. Bozza,

José Cerbino-Neto,

Patrı́cia T. Bozza,

Rita Maria Ribeiro Nogueira,

Patrícia Brasil,

Fabiano L. Thompson,

Ana María Bispo de Filippis,

Thiago Moreno L. Souza

Publication year - 2018

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/jgv.0.001080

Subject(s) - zika virus , biology , cerebrospinal fluid , flavivirus , virology , virus , neuropathology , titer , disease , immunology , saliva , pathology , medicine , neuroscience , biochemistry

Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).

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