Open AccessThe Relationship between Genomic RNAs of Polycythaemic Forms of Spleen Focus-forming Friend Virus and its Helper Virus
Author(s) -
J.G.J. Mol,
W. P. Vonk,
Ian B. Pragnell,
T.J. Stoof
Publication year - 1981
Publication title -
journal of general virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.55
H-Index - 167
eISSN - 1465-2099
pISSN - 0022-1317
DOI - 10.1099/0022-1317-54-2-367
Subject(s) - helper virus , biology , virology , friend virus , virus , genome , spleen , rnase p , rna , genetics , gene , viral replication , immunology
We have studied the relationship between Friend spleen focus-forming virus (SFFV) and its helper lymphoid leukaemia virus (LLV) by comparing RNase T1 fingerprints of genomic RNAs. Our data indicate that about 70% of the SFFV sequence is a perfect copy of parts of the helper genome. We conclude that our SFFV and LLV isolates have co-evolved very closely and that SFFV-specific sequences are not identical in different Friend virus isolates.