Human influenza virus NS1 protein enhances viral pathogenicity and acts as an RNA silencing suppressor in plants | Zendy

María Otilia Delgadillo | Zendy; Pilar Sáenz | Zendy; Beatriz Salvador | Zendy; Juan Antonio Garcı́a | Zendy; Carmen SimónMateo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Human influenza virus NS1 protein enhances viral pathogenicity and acts as an RNA silencing suppressor in plants

Author(s) -

María Otilia Delgadillo,

Pilar Sáenz,

Beatriz Salvador,

Juan Antonio Garcı́a,

Carmen SimónMateo

Publication year - 2004

Publication title -

journal of general virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.55

H-Index - 167

eISSN - 1465-2099

pISSN - 0022-1317

DOI - 10.1099/vir.0.19735-0

Subject(s) - biology , gene silencing , rna silencing , virology , rna interference , virus , rna induced silencing complex , tobacco etch virus , trans acting sirna , small interfering rna , rna , influenza a virus , plant virus , suppressor , nicotiana benthamiana , potyvirus , gene , genetics

RNA silencing has a well-established function as an antiviral defence mechanism in plants and insects. Using an Agrobacterium-mediated transient assay, we report here that NS1 protein from human influenza A virus suppresses RNA silencing in plants in a manner similar to P1/HC-Pro protein of Tobacco etch potyvirus, a well-characterized plant virus silencing suppressor. Moreover, we have shown that NS1 protein expression strongly enhances the symptoms of Potato virus X in three different plant hosts, suggesting that NS1 protein could be inhibiting defence mechanisms activated in the plant on infection. These data provide further evidence that an RNA silencing pathway could also be activated as a defence response in mammals.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research