Open AccessProtein Kinase C Inhibition Ameliorates Posttransplantation Preservation Injury in Rat Renal Transplants
Author(s) -
T. Florian Fuller,
Angelika Kusch,
Lyubov Chaykovska,
Rusan Catar,
Jennifer Pützer,
Martina Haller,
Jakob Troppmair,
Uwe Hoff,
Duska Dragun
Publication year - 2012
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318265c4d8
Subject(s) - transplantation , kidney , protein kinase c , medicine , cold storage , pharmacology , cytoprotection , renal function , reperfusion injury , ischemia , kinase , biology , biochemistry , oxidative stress , horticulture
Prolonged cold preservation frequently causes delayed renal graft function resulting from tubular epithelial injury. Inhibition of signal transduction downstream from protein kinase C (PKC) may reduce renal ischemia-reperfusion injury and confer renal graft protection. We therefore evaluated the effect of sotrastaurin, a small-molecule inhibitor of Ca²⁺-dependent and Ca²⁺-independent PKC isoforms, in comparison with mycophenolic acid (MPA) on rat renal transplants with prolonged cold preservation.