Open AccessB-cell Deficiency Attenuates Transplant Glomerulopathy in a Rat Model of Chronic Active Antibody-mediated Rejection
Author(s) -
Shan Reese,
Nancy A. Wilson,
Yabing Huang,
Lucille Ptak,
Kenna R. Degner,
Xiang Ding,
Robert Redfield,
Weixiong Zhong,
Sarah E. Panzer
Publication year - 2021
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003530
Subject(s) - immunology , pathogenesis , b cell , population , antibody , t cell , kidney , monocyte , medicine , transplantation , cell , kidney transplantation , biology , immune system , environmental health , genetics
Transplant glomerulopathy (TG) is a pathological feature of chronic active antibody-mediated rejection (cAMR) and is associated with renal allograft failure. The specific role of B cells in the pathogenesis of TG is unclear.