Open AccessIL-17A Is Critical for CD8+ T Effector Response in Airway Epithelial Injury After Transplantation
Author(s) -
Ruochan Zhang,
Huihui Fang,
Rongjuan Chen,
Jordi Ochando,
Yaozhong Ding,
Jiangnan Xu
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002452
Subject(s) - granzyme b , granzyme , cd8 , immunology , lung transplantation , perforin , cytotoxic t cell , alloimmunity , transplantation , respiratory epithelium , t cell , medicine , chemokine , biology , pathology , immune system , epithelium , biochemistry , in vitro
Airway epithelium is the primary target of trachea and lung transplant rejection, the degree of epithelial injury is closely correlated with obliterative bronchiolitis development. In this study, we investigated the cellular and molecular mechanisms of IL-17A-mediated airway epithelial injury after transplantation.