Open AccessCryoprecipitate attenuates the endotheliopathy of trauma in mice subjected to hemorrhagic shock and trauma
Author(s) -
Mark Barry,
Alpa Trivedi,
Byron Miyazawa,
Lindsay Vivona,
Manisha Khakoo,
Haoqian Zhang,
Praneeti Pathipati,
Anil Bagri,
Michelle G Gatmaitan,
Rosemary A. Kozar,
Deborah M. Stein,
Shibani Pati
Publication year - 2021
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.25
H-Index - 187
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000003164
Subject(s) - cryoprecipitate , medicine , fresh frozen plasma , pharmacology , in vivo , vascular permeability , inflammation , immunology , endothelium , fibrinogen , thrombin , platelet , pathology , biology , microbiology and biotechnology
Plasma has been shown to mitigate the endotheliopathy of trauma. Protection of the endothelium may be due in part to fibrinogen and other plasma-derived proteins found in cryoprecipitate; however, the exact mechanisms remain unknown. Clinical trials are underway investigating early cryoprecipitate administration in trauma. In this study, we hypothesize that cryoprecipitate will inhibit endothelial cell (EC) permeability in vitro and will replicate the ability of plasma to attenuate pulmonary vascular permeability and inflammation induced by hemorrhagic shock and trauma (HS/T) in mice.