Open AccessNeutrophil Extracellular Trap Formation and Syndecan-1 Shedding Are Increased After Trauma
Author(s) -
Julie Goswami,
Taleen A. MacArthur,
Kent R. Bailey,
Grant M. Spears,
Rosemary A. Kozar,
Matthew Auton,
Jing–fei Dong,
Nigel S. Key,
Stephanie F. Heller,
Erica A. Loomis,
Nathan W Hall,
Andrea L. Johnstone,
Myung S. Park
Publication year - 2021
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001741
Subject(s) - neutrophil extracellular traps , interquartile range , andrology , medicine , extracellular , thrombin generation , chemistry , gastroenterology , thrombin , inflammation , platelet , biochemistry
Damage-associated molecular patterns (DAMPs) stimulate endothelial syndecan-1 shedding and neutrophil extracellular traps (NET) formation. The role of NETs in trauma and trauma-induced hypercoagulability is unknown. We hypothesized that trauma patients with accelerated thrombin generation would have increased NETosis and syndecan-1 levels.