Open AccessPain-related behavior is associated with increased joint innervation, ipsilateral dorsal horn gliosis, and dorsal root ganglia activating transcription factor 3 expression in a rat ankle joint model of osteoarthritis
Author(s) -
Valerie Bourassa,
Haley Deamond,
Noosha Yousefpour,
MaryAnn Fitzcharles,
Alfredo RibeirodaSilva
Publication year - 2020
Publication title -
pain reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.113
H-Index - 15
ISSN - 2471-2531
DOI - 10.1097/pr9.0000000000000846
Subject(s) - medicine , allodynia , spinal cord , neuropathic pain , gliosis , osteoarthritis , nociception , hyperalgesia , chronic pain , anesthesia , neuroscience , pathology , anatomy , biology , physical therapy , receptor , alternative medicine , psychiatry
Supplemental Digital Content is Available in the Text. In a rat model of osteoarthritis, we found increased joint sensory and sympathetic innervation and glia changes in dorsal horn, accompanying pain-related behavior onset.