Open AccessLOXL1-associated Candidate Epithelial Pathomechanisms in Exfoliation Glaucoma
Author(s) -
Rozália Laczkó,
Kornélia Molnárné Szauter,
Katalin Csiszár
Publication year - 2014
Publication title -
journal of glaucoma
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.11
H-Index - 88
eISSN - 1536-481X
pISSN - 1057-0829
DOI - 10.1097/ijg.0000000000000105
Subject(s) - glaucoma , extracellular matrix , medicine , phenotype , epithelial–mesenchymal transition , microbiology and biotechnology , exfoliation joint , pathology , cancer research , ophthalmology , biology , genetics , nanotechnology , gene , graphene , materials science , cancer , metastasis
Results of the present study support ocular epithelia-specific LOXL1 functions in exfoliation glaucoma that may include both dysregulated extracellular matrix cross-linking activity and cellular mechanisms involving a role for LOXL1, in direct interaction with Snail1, in promoting epithelial to mesenchymal transition and a potential shift towards fibrogenic epithelial cell phenotypes.