Open AccessEffects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome
Author(s) -
Aleksi J Nummela,
Lauri Laaksonen,
Timo Laitio,
Roosa E. Kallionpää,
Jaakko Långsjö,
Joonas M Scheinin,
Tero Vahlberg,
Harri Koskela,
Viljami Aittomäki,
Katja Valli,
Antti Revonsuo,
Mikko Niemi,
Markus Perola,
Harry Scheinin
Publication year - 2021
Publication title -
european journal of anaesthesiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 76
eISSN - 1365-2346
pISSN - 0265-0215
DOI - 10.1097/eja.0000000000001591
Subject(s) - medicine , propofol , sevoflurane , ketamine , metabolite , metabolome , dexmedetomidine , isoflurane , ketogenesis , ketone bodies , pharmacology , xylazine , anesthesia , metabolism , sedation
Pharmacometabolomics uses large-scale data capturing methods to uncover drug-induced shifts in the metabolic profile. The specific effects of anaesthetics on the human metabolome are largely unknown.