Open AccessClinical consequences of asymptomatic cytomegalovirus in treated human immunodeficency virus infection
Author(s) -
Samuel R Schnittman,
Peter W. Hunt
Publication year - 2021
Publication title -
current opinion in hiv and aids
Language(s) - English
Resource type - Journals
eISSN - 1746-6318
pISSN - 1746-630X
DOI - 10.1097/coh.0000000000000678
Subject(s) - medicine , cytomegalovirus , immunology , immune system , disease , asymptomatic , human cytomegalovirus , inflammation , systemic inflammation , virus , intensive care medicine , viral disease , herpesviridae
Despite antiretroviral therapy (ART)-mediated viral suppression, people with human immunodeficiency virus (HIV) (PWH) have increased morbidity and mortality. Immune activation and inflammation persist on ART and predict these complications. Over 90% of PWH have cytomegalovirus (CMV) co-infection, and CMV is considered a plausible contributor to this persistent immune activation.