Open AccessIntestinal epithelial chemokine (C-C motif) ligand 7 overexpression protects against high fat diet-induced obesity and hepatic steatosis in mice
Author(s) -
Zhihong Luo,
Mengwei Niu,
Shenhai Gong,
Guangyan Wu,
Teng Wang,
Fangzhao Wang,
Guoquan Wei,
Zhanke He,
Yong Jiang,
Peng Chen
Publication year - 2020
Publication title -
chinese medical journal/chinese medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.537
H-Index - 63
eISSN - 2542-5641
pISSN - 0366-6999
DOI - 10.1097/cm9.0000000000000915
Subject(s) - ccl7 , steatosis , medicine , adipose tissue , endocrinology , biology , nonalcoholic fatty liver disease , diet induced obese , fatty liver , chemokine , insulin resistance , obesity , inflammation , cxcl10 , disease
We previously found that the intestinal epithelial chemokine (C-C motif) ligand 7 (CCL7) plays an important role in the development of toxin-induced acute liver damage. The detailed effects of intestinal epithelial CCL7 on chronic diseases; however, are still unclear. Here, we aimed to investigate the impact of intestinal epithelial CCL7 overexpression on high-fat diet (HFD)-induced obesity and steatohepatitis in mice.