Open AccessBlood and urine biomarkers in osteoarthritis – an update on cartilage associated type II collagen and aggrecan markers
Author(s) -
A.-C. Bay-Jensen,
Ali Mobasheri,
Christian S. Thudium,
Virginia B. Kraus,
Morten Karsdal
Publication year - 2021
Publication title -
current opinion in rheumatology/current opinion in rheumatology, with evaluated medline
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.452
H-Index - 112
eISSN - 1080-8175
pISSN - 1040-8711
DOI - 10.1097/bor.0000000000000845
Subject(s) - aggrecan , osteoarthritis , cartilage , type ii collagen , medicine , biomarker , disease , cartilage oligomeric matrix protein , articular cartilage , bioinformatics , pathology , biology , biochemistry , anatomy , alternative medicine
Osteoarthritis (OA) is a painful disease for which drug development has proven difficult. One major reason for this is the heterogeneity of the disease and the current lack of operationalized means to distinguish various disease endotypes (molecular subtypes). Biomarkers measured in blood or urine, reflecting joint tissue turnover, have been developed and tested during the last decades. In this narrative review, we provide highlights on biomarkers derived from the two most studied and abundant cartilage proteins - type II collagen and aggrecan.