Open AccessFTY720 reduces T-cell recruitment into murine intestinal allograft and prevents activation of graft-infiltrating cells
Author(s) -
T. Kimura,
Toshimichi Hasegawa,
Hiroshi Nakai,
Tatsuo Azuma,
Noriaki Usui,
Takashi Sasaki,
Akira Okada
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000058816.13525.92
Subject(s) - lamina propria , immunosuppression , intraepithelial lymphocyte , mesenteric lymph nodes , transplantation , lymphocyte , cd8 , immunology , medicine , t cell , monoclonal antibody , small intestine , il 2 receptor , biology , pathology , immune system , antibody , epithelium
Effective immunosuppression is a critical determinant of graft survival in small-bowel transplantation (SBTx). The present study was designed to determine the potency of FTY720, a newly synthesized immunosuppressant, in rat SBTx and examine the phenotype of graft-infiltrating cells to evaluate its effect on intestinal allografts.