Open AccessP1551: CONFORMATIONAL STUDY OF PYRUVATE KINASE DEFICIENT VARIANTS WITH HEMOLYTIC ANEMIA. THE RELATIONSHIPS BETWEEN THE LOSS OF ENZYME FUNCTION AND STRUCTURAL DISRUPTION
Author(s) -
Jorda L.,
Montllor L.,
Krisnevskaya E.,
Leguizamón V.,
Hernandez I.,
Gelpi J. L.,
Vives Corrons J.L.
Publication year - 2022
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/01.hs9.0000849060.64856.dd
Subject(s) - allosteric regulation , pyruvate kinase deficiency , missense mutation , activator (genetics) , hemolysis , enzyme , mutation , pyruvate kinase , point mutation , structural similarity , hemolytic anemia , biochemistry , phenotype , chemistry , biology , gene , glycolysis , immunology