Open AccessProphylactic Effect of Intravenous Nicorandil on Perioperative Myocardial Damage in Patients Undergoing Off-Pump Coronary Artery Bypass Surgery
Author(s) -
Isao Ito,
Yukio Hayashi,
Yusuke Kawai,
Takahiko Kamibayashi,
Goro Matsumiya,
Tetsuya Takahashi,
Hikaru Matsuda,
Takashi Mashimo
Publication year - 2004
Publication title -
journal of cardiovascular pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.762
H-Index - 100
eISSN - 1533-4023
pISSN - 0160-2446
DOI - 10.1097/01.fjc.0000141476.52125.5b
Subject(s) - nicorandil , medicine , perioperative , cardiology , artery , troponin t , creatine kinase , anesthesia , off pump coronary artery bypass , troponin i , hemodynamics , angina , bypass grafting , myocardial infarction
Nicorandil, ATP sensitive potassium channel opener, is shown to reduce coronary events for patients with stable angina. The present study was designed to examine the protective potential of nicorandil for patients undergoing off-pump coronary artery bypass grafting. Twenty-four patients undergoing off-pump coronary artery bypass grafting were randomly assigned to two groups, one receiving continuous infusion of nicorandil (1.0 microg.kg(-1).min(-1)) (n = 12) through anesthesia to next day and the other receiving no nicorandil for control (n = 12). For assessing myocardial injury, heart type fatty acid binding protein, troponin T, and creatine kinase MB isoform were determined during the first 15 hours after reperfusion. The concentration of heart type fatty acid binding protein in the nicorandil group was significantly lower than that in the control group. On the other hand, the concentrations of troponin T and creatine kinase MB isoform in the nicorandil group were lower than those in the control group, but the differences did not reach statistical significance. Furthermore, nicorandil did not affect the patients' hemodynamic variables. Our data suggest that the infusion of nicorandil provides small myocardial protection without affecting hemodynamic parameters during perioperative treatment of patients undergoing off-pump coronary artery bypass grafting.