Open AccessCase-Control Studies of the Efficacy of Cancer Screening
Author(s) -
Noel S. Weiss,
Preet K. Dhillon,
Ruth Etzioni
Publication year - 2004
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/01.ede.0000129518.99816.e1
Subject(s) - confounding , medicine , test (biology) , cancer , screening test , cancer screening , pediatrics , biology , paleontology
A case-control study of the efficacy of cancer screening, like any other case-control study, must deal with potential confounding. There are 2 categories of confounding variables that pose special problems for studies of screening: (1) age and calendar time resulting from different temporal distributions of screening between cases and controls irrespective of whether the screening test leads to a reduction in mortality; and (2) the administration of other screening tests for the cancer in question when it is not clear whether the result of the other test had a bearing on the decision to order the test under study. We describe circumstances in which confounding from these sources can be dealt with satisfactorily by means of restriction or adjustment, and other circumstances in which it cannot.