Open AccessIndinavir protein-free concentrations when used in indinavir/ritonavir combination therapy
Author(s) -
Jennifer R. King,
John G. Gerber,
Courtney V. Fletcher,
Lane R. Bushman,
Edward P. Acosta
Publication year - 2005
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000174452.78497.54
Subject(s) - cmax , indinavir , ritonavir , pharmacokinetics , free fraction , in vivo , chemistry , pharmacology , medicine , biology , sida , human immunodeficiency virus (hiv) , immunology , viral disease , antiretroviral therapy , viral load , microbiology and biotechnology
To describe the in vivo protein-binding characteristics of indinavir (IDV) in the presence of ritonavir (RTV) relative to total IDV plasma concentrations.