Open AccessPharmacokinetic Interaction Between Nevirapine and Ethinyl Estradiol/Norethindrone When Administered Concurrently to HIV-Infected Women
Author(s) -
Donna Mildvan,
Robert Yarrish,
Ann Marshak,
H. Wayne Hutman,
Marita McDonough,
Michael Lamson,
Patrick Robinson
Publication year - 2002
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/00126334-200204150-00007
Subject(s) - pharmacokinetics , nevirapine , medicine , norethisterone , reverse transcriptase inhibitor , pharmacology , oral administration , area under the curve , population , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , immunology , health services , environmental health
To determine the effects of nevirapine (NVP), a nonnucleoside reverse-transcriptase inhibitor of HIV-1 and P450 inducer, on the pharmacokinetics (PK) of ethinyl estradiol (EE)/norethindrone (NET), a widely used oral contraceptive, and to assess the effects of EE/NET on the steady-state PK of NVP.