Open AccessREPROGRAMMING OF GENE EXPRESSION IN CULTURED CARDIOMYOCYTES AND IN EXPLANTED HEARTS BY THE MYOSIN ATPASE INHIBITOR BUTANEDIONE MONOXIME
Author(s) -
Thomas Thum,
Jürgen Borlak
Publication year - 2001
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/00007890-200102270-00010
Subject(s) - myosin light chain kinase , gene expression , myosin , biology , myh6 , creatine kinase , ectopic expression , regulation of gene expression , microbiology and biotechnology , gene , myh7 , medicine , endocrinology , biochemistry
Butanedione monoxime (BDM) is a reversible myosin ATPase inhibitor. Its use in transplantation medicine may be of benefit in the preservation of hearts. As little is known about its ability to prevent stress and metabolic deregulation, we wanted to investigate the genomic response in cultured cardiomyocytes and explanted, preserved hearts at the transcriptional level.