Open AccessViral load response to a pneumococcal conjugate vaccine, polysaccharide vaccine or placebo among HIV-infected patients
Author(s) -
Matthew Bidwell Goetz,
Daniel R. Feikin,
Jeffrey L. Lennox,
William A. O’Brien,
Cheryl M. Elie,
Jay C. Butler,
Robert F. Breiman
Publication year - 2002
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/00002030-200207050-00015
Subject(s) - viral load , pneumococcal conjugate vaccine , placebo , medicine , pneumococcal vaccine , virology , immunology , immunization , lentivirus , immunogenicity , viral disease , streptococcus pneumoniae , human immunodeficiency virus (hiv) , antigen , biology , microbiology and biotechnology , antibiotics , alternative medicine , pathology
We determined the HIV viral load in 66 adults randomly assigned to receive pneumococcal immunization with one or two doses of protein conjugate vaccine, one dose of polysaccharide vaccine, one dose of each, or placebo. Second doses were given 8 weeks after the first. Mean baseline viral load and CD4 cell count were 3.41 copies/ml (log10) and 457 cells/microl, respectively. We found no change in viral load during 24 weeks of follow-up for any vaccine or combination of vaccines or placebo.