Open AccessSingle-copy assay quantification of HIV-1 RNA in paired cerebrospinal fluid and plasma samples from elite controllers
Author(s) -
Viktor Dahl,
Julia Peterson,
Serena Spudich,
Evelyn Lee,
Barbara L. Shacklett,
Richard W. Price,
Sarah Palmer
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32835cf235
Subject(s) - cerebrospinal fluid , rna , lentivirus , blood plasma , biology , human immunodeficiency virus (hiv) , viral load , virology , immunology , microbiology and biotechnology , medicine , viral disease , pathology , endocrinology , gene , biochemistry
Elite controllers are a rare subset of HIV-1-infected individuals who maintain HIV-1 RNA concentrations in plasma below the lower limit of quantification of clinical assays (<20-50 copies/ml) in the absence of antiretroviral therapy. Here, we examine to what extent elite controllers also control infection of the central nervous system (CNS).
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