The impact of immune modulators from the group of substituted thiadiazines on the severity of stress reaction (1054.7)

Central mode stress relieving effect of immune modulators from the group of substituted thiadiazines. Stress reaction is characterized by a number of changes on the part of immune system in the form of high concentration of neutrophils, decreasing aggregate amount of lymphocytes, as well as appearance of catecholamine block of pancreas α‐receptors, which at the early stages of stress causes the so‐called «strain diabetes», and at its final stage (stage of exhaustion), progress of typical «steroid diabetes». Previous studies demonstrated that the main effect mechanism of compounds from the group of substituted thiadiazines is their capability to modulate inflammation process. The goal of the present research was the evaluation of their effect on the course of stress reaction. The experiment was conducted by the pattern of 6‐hour and 48‐hour immobilization stress with rats. The animals got injection of the compounds, dozed 40 mg/kg. Histological study and biochemical analysis has been carried out at the 6 and 48 hours of the experiment. On the background of compounds introduction, we detected lowering level of corticosterone, changes in the histomorphology of lymphopoiesis organs, as well as increase in the number of lymphocyte and monocyte series in the setting of decreasing number of eosinophils in the blood. The conducted research allowed to assume the existence of central effect mechanism of immune modulators from the group of substituted thiadiazines. Grant Funding Source : Supported by grant 12‐M‐34‐2064