HYDROGEN SULFIDE (H2S) IMPROVES THE RENAL FUNCTION IN A COMBINED STATE OF HYPERTENSION AND DIABETES | Zendy

Rathore Hassaan Anwer | Zendy; Din Fiaz ud | Zendy; Abdullah Mohammed H | Zendy; Zubaid Munavvar | Zendy; Abdullah Nor Azizan | Zendy; Johns Edward J | Zendy

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HYDROGEN SULFIDE (H2S) IMPROVES THE RENAL FUNCTION IN A COMBINED STATE OF HYPERTENSION AND DIABETES

Author(s) -

Rathore Hassaan Anwer,

Din Fiaz ud,

Abdullah Mohammed H,

Zubaid Munavvar,

Abdullah Nor Azizan,

Johns Edward J

Publication year - 2012

Publication title -

the faseb journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.709

H-Index - 277

eISSN - 1530-6860

pISSN - 0892-6638

DOI - 10.1096/fasebj.26.1_supplement.1131.12

Subject(s) - streptozotocin , medicine , endocrinology , spontaneously hypertensive rat , diabetes mellitus , blood pressure , sodium hydrosulfide , renovascular hypertension , mean arterial pressure , renal function , chemistry , heart rate , hydrogen sulfide , sulfur , organic chemistry

This study investigated the action of H2S on mean arterial pressure (MAP) and renal function in a combined state of hypertension and diabetes. Groups (n=6) of spontaneously hypertensive rats (SHR) or Wistar Kyoto (WKY) rats received vehicle, streptozotocin (STZ)(40mg/kg) or STZ plus Sodium Hydrogen Sulphide (NaHS), at 56μmol/Kg i.p daily for 35 days; therafter, MAP and cortical blood perfusion (CBP) were measured in ketamine + xylazine anaesthetized rats. Data, mean±SEM, were subjected to ANOVA and significance set at p<0.05. MAP was similar in the WKY (104±1 mmHg), WKY‐STZ and WKY‐STZ‐NaHS groups as was CBP (163±2 BPU). MAP of SHR‐STZ was higher than SHR (145±2 vs 142±2 mmHg) but was lower in SHR‐STZ‐NaHS at 132±3mmHg (P<0.05). CBP in the SHR‐STZ was lower than the SHR (138±3 vs 150±3BPU) but was 12% higher than SHR‐STZ (P<0.05) in SHR‐STZ‐NaHS. GFR in the WKY‐STZ‐NaHS was higher (P<0.05) than the WKY‐STZ (1.8±0.07 vs 0.7±0.02 ml/min/100g). In the SHR‐STZ‐NaHS GFR was higher (P<0.05) than in SHR‐STZ, 2±0.1 vs 1.2±0.1 ml/min/100g. The improved renal function with NaHS was likely due to the vasodilator effect of H2S reducing renovascular resistance and improving the renal blood flow in hypertension concomitant with diabetes in rats.

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