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Initiative to Link Animal Models to Human Disease (LAMHDI) Search Engine, a Critical Research Resource
Author(s) -
Anderson David Michael,
Kemnitz J.,
Tyers M.,
Ellisman M.,
Grethe J.S.,
Martone M.,
ChatrAryamontri A.,
Bandrowski A.,
Iadonado S.,
Larson S.R.,
Magness C.,
Troyanskaya O.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.793.20
LAMHDI.org , a free web‐based resource, helps translational researchers bridge the gap between model organisms and human disease. The LAMHDI portal builds on genetic linkages between models across species (non‐human primates, zebrafish, mice, rats, flies, and yeast, with others in the pipeline) using homologous genes to span humans and animal models. New work includes matching specific phenotypes and common pathways, a zebrafish atlas, and a graphical search based on spatial models of the brain. Companion efforts will speed the discovery and validation of novel drug candidates in areas as diverse as infectious disease, neuroscience, cardiovascular and metabolic disorders, autoimmunity, and cancer. For example, a search for the breast cancer gene brca1 finds specific models including a mouse strain from JAX, a zebrafish model from ZFIN (through the Bard1 genes) in rats, flies, and yeast. Each search result presents a specific model, related alleles, and links to an associated vendor. This poster represents the work of the authors and other members of the LAMHDI team. This work is supported by contract HHSN268200800014C from NIH/NCRR.