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Barosensitive neurons in the rat lateral tegmental field
Author(s) -
Hopp Francis,
Dean Caron,
Seagard Jeanne
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.1075.18
Subject(s) - baroreceptor , premovement neuronal activity , chemistry , ventral tegmental area , brainstem , neuroscience , heart rate , anatomy , blood pressure , medicine , biology , dopaminergic , dopamine
Earlier studies have shown that activation of neurons in the lateral tegmental field (LTF) evoke changes in blood pressure (BP) and heart rate in the rat (Marchenko, V, et al. 2003) and sympathetic nerve discharge (SND) in the cat (Orer, H.S.et al 1999). Neuronal recordings in the cat indicate that LTF neurons respond to activation of baroreceptors and/or chemoreceptors. This study was performed to determine whether neurons in the LTF in rats respond to changes in perfusion pressure (PP) in the working heart brainstem preparation, indicating a potential role in central barosensitive pathways. LTF neurons were studied using a multibarrel pipette which allowed picoejection of AMPA to verify neuronal status and dye to mark recording sites, as well as a carbon fiber to record activity. Recordings were initiated at 0.6–1.0 mm rostral, 1.0–1.2 mm lateral and 1.4–2.4 mm deep relative to calamus scriptorius. Of the 11 barosensitive neurons recorded, 7 increased discharge and 4 decreased discharge to increases in PP. All increased activity to AMPA, indicating neuronal status. Results indicate a barosensitivity of LTF neurons that could contribute to either an increase or decrease in SND. Supported by VA, VHA, ORD, BLR&D; NSF award IOS 0751613