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Sympathoexcitatory outflow from the Rostral Ventrolateral Medulla is attenuated in aged Wistar‐Kyoto Rats
Author(s) -
Yajima Yoshiharu,
Komatsu Kazutoshi,
Suzuki Toshirou,
Kanai Takashi,
Hiratsuka Makoto,
Ito Satoru,
Tsukamoto Kazuyoshi,
Hirayama Atushi
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.737.31
Subject(s) - rostral ventrolateral medulla , microinjection , vasomotor , medulla oblongata , medicine , endocrinology , glutamate receptor , stimulation , baroreflex , phenylephrine , medulla , anesthesia , central nervous system , heart rate , blood pressure , receptor
The rostral ventrolateral medulla (RVLM) vasomotor neurons are responsible for maintaining the tonic excitation of sympathetic preganglionic neurons. It is well known that the aging causes the physiological alternation in cardiovascular regulation. However, the cardiovascular influence of central vasomotor neurons in the advanced aged animals are not fully examined. In this study, using more than 80 weeks old Wistar‐Kyoto rats (WKY) as high aged model, we sought to determine the cardiovascular response of RLVM in glutamatergic stimulation. In alpha‐chloralose‐anesthetized animals, microinjection of glutamate into unilateral RVLM were performed. In elderly WKY rats, although the intravenous injection of sodium nitroprusside or phenylephrine evoked similar response of the groups of animals in 16–20 weeks old, the response evoked by microinjection of glutamate into RVLM were smaller than that of control. These results suggest the sympathoexcitatory influence from RVLM is attenuated in advanced aged animals.
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