Premium
Effects of a high‐protein diet with or without monosodium‐glutamate in combination with inosine‐monophosphate‐5 on 24‐h energy and appetite profile
Author(s) -
Lejeune Manuela,
Smeets Astrid,
WesterterpPlantenga Margriet
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a56-c
Subject(s) - appetite , medicine , monosodium glutamate , endocrinology , inosine monophosphate , energy expenditure , chemistry , zoology , food science , biology , biochemistry , nucleotide , gene
The aim of the present study was to determine if addition of monosodium‐glutamate (MSG) in combination with inosine‐monophosphate‐5 (IMP‐5) to a high protein diet has an effect on energy expenditure and appetite profile. Twelve subjects (6 male/6 female; age: 26 ± 9 yr, BMI: 22.6 ± 2.2 kg/m 2 ) were fed a high‐protein diet during three 36‐h respiration chamber experiments. In a randomized cross‐over design they received a lunch without MSG+IMP‐5, a lunch with MSG+IMP‐5 added to the food, and a lunch with MSG+IMP‐5 in capsules. The concentrations MSG and IMP‐5 added were 0.6% [w/w] and 0.25% [w/w] respectively. Energy expenditure and its components and the appetite profile were measured. Desire to eat (24‐h area under the curve) was significantly higher in the high‐protein diet without MSG+IMP‐5 compared to the high‐protein diet with MSG+IMP‐5 added to the food (1079 ± 344 versus 833 ± 372, p<0.05). No significant differences were seen in hunger, satiety, fullness or prospective consumption between the three conditions. With respect to energy expenditure and its component no significant differences were found between the three conditions. We conclude that addition of MSG+IMP‐5 to a high protein diet has no effect on energy expenditure and only minor effects on appetite profile.