Premium
The Expression of MRPL42 in Glioma and Its Prognostic Analysis
Author(s) -
Duan Hubin,
Hao Chunyan,
Qiao Xiaohong,
Wang Hongqin,
Xue Wen,
Lu Jian,
Zhang Jinbao,
Zhang Huaping,
Zhang Ce
Publication year - 2020
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2020.34.s1.00047
Subject(s) - glioma , china , immunohistochemistry , medicine , oncology , cancer research , political science , law
Objective To determine the correlation between mitochondrial ribosomal protein MRPL42 expression levels in glioma and its association with clinicopathological parameters and prognosis. Methods immunohistochemistry assays were performed to explore the MRPL42 levels among diverse World Health Organization (WHO) grade of glioma, and its correlation with clinicopathological characteristics and survival prognosis of patients was also analyzed. Results The results of immunohistochemistry analysis indicated that the expression of MRPL42 was positively correlated with glioma WHO grade(P<0.05) and several malignant clinicopathological index including Ki67 and P53mut. Besides, Kaplan‐Meier survival analysis also illustrated that patients with high expression of MRPL42 had significantly shorter overall survival than those with low expression of MRPL42(P<0.05). Conclusion The expression of MRPL42 not only showed a tumor grade and clinicopathological factors‐dependent pattern, but also existed a positive correlation between them and distinguished glioma with poor prognosis, which may serve as prognostic biomarkers and potential therapeutic targets in glioma. Support or Funding Information • This study was supported by the National Natural Science Foundation Youth Fund (30600637), China Postdoctoral Science Foundation Grant (2019T120195), China Postdoctoral Science Foundation Grant (2014M561207), the Shanxi Province Basic Research Program ( 2010021034‐4, 201601D011119), the Shanxi Scholarship Council of China (2011‐096 and Key Projects No. 4), Department of Human Resources and Social Security of Shanxi province, The science and technology research projects of health department of Shanxi Province (2016D011119), The Teaching Reform Program of Shanxi Higher Education, The Education Reform Project of Postgraduate Students in Shanxi Province. The Project of “131” Leading Talents of Shanxi Higher Education, The Education Reform Project of Shanxi Medical University.