Effect of Buyang Huanwu Decoction on Renal Injury in Spontaneously Hypertensive Rats

Hypertension is an independent risk factor contributing to chronic kidney disease. Buyang Huanwu Decoction (BHD) is a popular traditional Chinese medicine prescription for the treatment of stroke for centuries. Recent studies reported that the use of BHD had been extended to treat various kinds of disorders following traditional Chinese medicine syndrome theory of Treating Different Diseases with the Same Method. Therefore, this study aimed to determine the effects of BHD on renal injury in spontaneously hypertensive rats (SHR). Treatment with BHD at the dose of 12.6 g/kg/day by gavage for 5 weeks had no effect on the increased systolic blood pressure and renal hypertrophy in 17‐week‐old SHR. However, BHD treatment obviously reduced urinary albumin excretion compared with the control SHR ( P <0.05). Periodic acid‐Schiff and Masson's trichrome staining showed that obvious glomerulosclerosis and tubulointerstitial injury were found in the kidney in SHR and reduced by BHD treatment ( P <0.05). Consistent with the results, renal collagen level determined using hydroxyproline assay was higher in SHR and attenuated by BHD treatment ( P <0.05). In addition, the renal monocyte/macrophage infiltration was seen in SHR and inhibited by BHD treatment ( P <0.05). Our data showed that treatment with BHD attenuated renal damage in SHR independently of their effects on blood pressure. The results indicate that BHD exhibits a protective effect on renal damage in SHR. This work was supported in part by the National Natural Science Foundation of China (No. 81673734). Support or Funding Information This work was supported in part by the National Natural Science Foundation of China (No. 81673734). This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .