Open AccessKRAS and BRAF Mutations in Stage II and III Colon Cancer: A Systematic Review and Meta-Analysis
Author(s) -
Vincenzo Formica,
Francesco Sera,
Chiara Cremolini,
Silvia Riondino,
Cristina Morelli,
HendrikTobias Arkenau
Publication year - 2021
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djab190
Subject(s) - kras , medicine , hazard ratio , colorectal cancer , meta analysis , oncology , confidence interval , subgroup analysis , microsatellite instability , stage (stratigraphy) , proportional hazards model , cancer , biology , allele , genetics , microsatellite , paleontology , gene
KRAS and BRAF mutations are well-established predictive and prognostic factors in metastatic colorectal cancer; however, their impact in the adjuvant setting has not yet been established.