Open AccessEvaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry
Author(s) -
Zhaohui Du,
Guimin Gao,
Babatunde Adedokun,
Thomas U. Ahearn,
Kathryn L. Lunetta,
Gary Zirpoli,
Melissa A. Troester,
Edward A. Ruiz-Narváez,
Stephen A. Haddad,
Parichoy PalChoudhury,
Jonine D. Figueroa,
Esther M. John,
Leslie Bernstein,
Zheng Wang,
Jennifer J. Hu,
Regina G. Ziegler,
Sarah J. Nyante,
Elisa V. Bandera,
Sue A. Ingles,
Nicholas Mancuso,
Michael F. Press,
Sandra L. Deming,
Jorge L. Rodriguez-Gil,
Song Yao,
Temidayo O. Ogundiran,
Oladosu Ojengbe,
Manjeet K. Bolla,
Joe Dennis,
Alison M. Dunning,
Douglas F. Easton,
Kyriaki Michailidou,
Paul D.P. Pharoah,
Dale P. Sandler,
Jack A. Taylor,
Qin Wang,
Clarice R. Weinberg,
Cari M. Kitahara,
William J. Blot,
Katherine L. Nathanson,
Anselm Hennis,
Barbara Nemesure,
Stefan Ambs,
Lara E. SuchestonCampbell,
Jeannette T. Bensen,
Stephen J. Chanock,
Andrew F. Olshan,
Christine B. Ambrosone,
Olufunmilayo I. Olopade,
Joel Yarney,
Baffour Awuah,
Beatrice WiafeAddai,
David V. Conti,
Julie R. Palmer,
Montserrat García-Closas,
Dezheng Huo,
Christopher A. Haiman
Publication year - 2021
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djab050
Subject(s) - medicine , decile , confidence interval , demography , odds ratio , breast cancer , ancestry informative marker , percentile , receiver operating characteristic , genetic genealogy , genotype , cancer , allele frequency , population , genetics , environmental health , biology , statistics , gene , mathematics , sociology
Polygenic risk scores (PRSs) have been demonstrated to identify women of European, Asian, and Latino ancestry at elevated risk of developing breast cancer (BC). We evaluated the performance of existing PRSs trained in European ancestry populations among women of African ancestry.