Open AccessHuman Immunodeficiency Virus (HIV)–Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy
Author(s) -
Jenny L. Anderson,
Gabriela Khoury,
Rémi Fromentin,
Ajantha Solomon,
Nicolas Chomont,
Elizabeth Sinclair,
Jeffrey M. Milush,
Wendy Hartogensis,
Peter Bacchetti,
Michael Roche,
Carolin Tumpach,
Matthew Gartner,
Matthew C. Pitman,
C. Lorrie Epling,
Rebecca Hoh,
Frederick Hecht,
Ma Somsouk,
Paul Cameron,
Steven G. Deeks,
Sharon R. Lewin
Publication year - 2019
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz509
Subject(s) - c c chemokine receptor type 6 , ccl20 , chemokine receptor , cxcl13 , ccl17 , biology , chemokine , immunology , virology , ccl19 , ccr4 , cxcr4 , cxcr3 , immune system
Identifying where human immunodeficiency virus (HIV) persists in people living with HIV and receiving antiretroviral therapy is critical to develop cure strategies. We assessed the relationship of HIV persistence to expression of chemokine receptors and their chemokines in blood (n = 48) and in rectal (n = 20) and lymph node (LN; n = 8) tissue collected from people living with HIV who were receiving suppressive antiretroviral therapy.