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Central venous pressure and impaired renal function in patients with acute heart failure
Author(s) -
Uthoff Heiko,
Breidthardt Tobias,
Klima Theresia,
Aschwanden Markus,
Arenja Nisha,
Socrates Thenral,
Heinisch Corinna,
Noveanu Markus,
Frischknecht Barbara,
Baumann Ulrich,
Jaeger Kurt A.,
Mueller Christian
Publication year - 2011
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1093/eurjhf/hfq195
Subject(s) - medicine , central venous pressure , renal function , concomitant , heart failure , ejection fraction , cardiology , blood pressure , creatinine , natriuretic peptide , acute decompensated heart failure , heart failure with preserved ejection fraction , heart rate
Aims To determine the relationship between central venous pressure (CVP) and renal function in patients with acute heart failure (AHF) presenting to the emergency department. Methods and results Central venous pressure was determined non‐invasively using compression sonography in 140 patients with AHF at presentation. Worsening renal function (WRF) was defined as an increase in serum creatinine ≥0.3 mg/dL during hospitalization. In the study cohort [age 77 ± 12 years, B‐type natriuretic peptide 1862 ± 1564 pg/mL, left ventricular ejection fraction 40 ± 15%, estimated glomerular filtration rate (eGFR) 58 ± 28 mL/min, and CVP 13.2 ± 6.9 cmH 2 O], 51 patients (36%) developed WRF. No significant association between CVP at presentation or discharge and concomitant eGFR ( r = 0.005, P = 0.419 and r = 0.013, P = 0.313, respectively) was observed. However, in patients with systolic blood pressure (SBP) <110 mmHg and concomitant high CVP (>15 cmH 2 O), eGFR was significantly lower at presentation and discharge (29 ± 17 vs. 47 ± 19 mL/min/1.73 m 2 , P = 0.039 and 26 ± 10 vs. 53 ± 26 mL/min/1.73 m 2 , P = 0.013, respectively). Central venous pressure at presentation and at discharge did not differ between patients with or without in‐hospital WRF (12.6 ± 7.2 vs. 13.5 ± 6.7 cmH 2 O, P = 0.503 and 7.4 ± 6.5 vs. 7.7 ± 5.7 cmH 2 O, P = 0.799, respectively) (receiver‐operating characteristic analysis 0.543, P = 0.401 and 0.531, P = 0.625, respectively). However, patients with CVP in the lowest tertile (<10 cmH 2 O) at presentation were more likely to develop WRF within the first 24 h than patients with CVP in the highest tertile (>15 cmH 2 O) (18 vs. 4%, P = 0.046). Conclusion In AHF, combined low SBP and high CVP predispose to lower eGFR. However, lower CVP may also be associated with short‐term WRF. The pathophysiology of WRF and the role of CVP seem to be more complex than previously thought.