Open AccessDifferential miRNA Expression in Ileal and Colonic Tissues Reveals an Altered Immunoregulatory Molecular Profile in Individuals With Crohn’s Disease versus Healthy Subjects
Author(s) -
Aylia Mohammadi,
Orlaith Kelly,
Michelle I. Smith,
Boyko Kabakchiev,
Mark S. Silverberg
Publication year - 2019
Publication title -
journal of crohn's and colitis
Language(s) - English
Resource type - Journals
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1093/ecco-jcc/jjz076
Subject(s) - microrna , crohn's disease , biopsy , biomarker , biology , gene expression , rna extraction , ileum , chemokine , medicine , inflammation , disease , pathology , gene , immunology , genetics
MicroRNAs [miRNAs] are key modulators of gene expression in Crohn's disease [CD] and may drive tissue-specific molecular alterations underlying CD susceptibility. In this study, we analysed differential miRNA expression between CD and healthy subjects across ileal and colonic tissues.