Open AccessGenetic association analysis of LRCH1 as an osteoarthritis susceptibility locus
Author(s) -
Sarah Snelling,
Janet S. Sinsheimer,
Andrew Carr,
John Loughlin
Publication year - 2006
Publication title -
lara d. veeken
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/kel265
Subject(s) - single nucleotide polymorphism , snp , osteoarthritis , genetics , locus (genetics) , genetic association , genotype , medicine , biology , gene , pathology , alternative medicine
A genetic association with knee osteoarthritis (OA) of a single nucleotide polymorphism (SNP) in intron 1 of the LRCH1 gene was recently reported in a UK Caucasian case-control sample and confirmed in a Newfoundland Caucasian sample. Our objective was to assess whether the SNP was associated with OA in our large UK Caucasian sample.
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