Extensive Gene Conversion Drives the Concerted Evolution of Paralogous Copies of the SRY Gene in European Rabbits | Zendy

Armando Geraldes | Zendy; T. Rambo | Zendy; Rod A. Wing | Zendy; Nuno Ferrand | Zendy; Michael W. Nachman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Extensive Gene Conversion Drives the Concerted Evolution of Paralogous Copies of the SRY Gene in European Rabbits

Author(s) -

Armando Geraldes,

T. Rambo,

Rod A. Wing,

Nuno Ferrand,

Michael W. Nachman

Publication year - 2010

Publication title -

molecular biology and evolution

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.637

H-Index - 218

eISSN - 1537-1719

pISSN - 0737-4038

DOI - 10.1093/molbev/msq139

Subject(s) - testis determining factor , biology , gene conversion , genetics , palindrome , gene , y chromosome , locus (genetics) , chromosome , concerted evolution , gene duplication , recombination , genome

The human Y chromosome consists of ampliconic genes, which are located in palindromes and undergo frequent gene conversion, and single-copy genes including the primary sex-determining locus, SRY. Here, we demonstrate that SRY is duplicated in a large palindrome in the European rabbit (Oryctolagus cuniculus). Furthermore, we show through comparative sequencing that orthologous palindrome arms have diverged 0.40% between rabbit subspecies over at least 2 My, but paralogous palindrome arms have remained nearly identical. This provides clear evidence of gene conversion on the rabbit Y chromosome. Together with previous observations in humans, these results suggest that gene conversion is a general feature of the evolution of the mammalian Y chromosome.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research