Quantitation of GSTP1 Methylation in Non-neoplastic Prostatic Tissue and Organ-Confined Prostate Adenocarcinoma | Zendy

Cármen Jerónimo | Zendy; Henning Usadel | Zendy; Rui Henrique | Zendy; Jorge Oliveira | Zendy; Carlos Lopes | Zendy; William G. Nelson | Zendy; David Sidransky | Zendy

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Quantitation of GSTP1 Methylation in Non-neoplastic Prostatic Tissue and Organ-Confined Prostate Adenocarcinoma

Author(s) -

Cármen Jerónimo,

Henning Usadel,

Rui Henrique,

Jorge Oliveira,

Carlos Lopes,

William G. Nelson,

David Sidransky

Publication year - 2001

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/93.22.1747

Subject(s) - gstp1 , intraepithelial neoplasia , prostate , adenocarcinoma , prostate cancer , methylation , biopsy , dna methylation , pathology , medicine , high grade prostatic intraepithelial neoplasia , cancer , hyperplasia , mesothelioma , biology , gene , gene expression , biochemistry , genotype

Methylation of regulatory sequences near GSTP1, which encodes the pi class glutathione S-transferase, is the most common epigenetic alteration associated with prostate cancer. We determined whether the quantitation of GSTP1 methylation in histopathologically distinct prostate tissue samples could improve prostate cancer detection.

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