Open AccessAnother Facet of Ubiquitylation: Death
Author(s) -
W. WeiLynn Wong,
John Silke
Publication year - 2009
Publication title -
journal of molecular cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 62
eISSN - 1759-4685
pISSN - 1674-2788
DOI - 10.1093/jmcb/mjp019
Subject(s) - ubiquitin ligase , ubiquitin , microbiology and biotechnology , facet (psychology) , cytosol , programmed cell death , sequestosome 1 , chromosomal translocation , chemistry , apoptosis , biology , autophagy , biochemistry , enzyme , gene , social psychology , psychology , personality , big five personality traits
Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequestosome-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.
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