Peripheral neuropathy in patients on long-term triazole antifungal therapy
Author(s) -
Caroline Baxter,
A. Marshall,
Mary M. Roberts,
Tim Felton,
David W. Denning
Publication year - 2011
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkr233
Subject(s) - medicine , aspergillosis , voriconazole , posaconazole , itraconazole , incidence (geometry) , surgery , retrospective cohort study , context (archaeology) , mycosis , dermatology , antifungal , immunology , paleontology , physics , optics , biology
Triazole antifungal drugs are the mainstay of treatment for patients with chronic pulmonary aspergillosis and are often used as steroid-sparing agents in patients with allergic aspergillosis. Peripheral neuropathy (PN) is a rare but reported side effect of triazole therapy in the acute management of invasive fungal infections, but its incidence during long-term triazole treatment for chronic aspergillosis is unknown. The goal of this study was to determine the incidence of PN in this context.
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