Epidemiology-based risk assessment using the benchmark dose/margin of exposure approach: the example of ethanol and liver cirrhosis | Zendy

Dirk W. Lachenmeier | Zendy; Fotis Kanteres | Zendy; Jürgen Rehm | Zendy

Open Access

Epidemiology-based risk assessment using the benchmark dose/margin of exposure approach: the example of ethanol and liver cirrhosis

Author(s) -

Dirk W. Lachenmeier,

Fotis Kanteres,

Jürgen Rehm

Publication year - 2010

Publication title -

international journal of epidemiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.406

H-Index - 208

eISSN - 1464-3685

pISSN - 0300-5771

DOI - 10.1093/ije/dyq150

Subject(s) - medicine , epidemiology , risk assessment , environmental health , population , cohort study , cohort , computer science , computer security

A novel approach to derive a threshold dose with respect to alcohol-related harm, the benchmark dose (BMD) methodology, is introduced to provide a basis for evidence-based drinking guidelines. This study is the first to calculate a BMD for alcohol exposure using epidemiological cohort data. With this BMD we will be able to calculate the margin of exposure (MOE) for alcohol consumption, which can be used for comparative risk assessment and applied to setting public health policy.

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